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Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

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Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Dysrhythmias II: Classification of Tachyarrhythmias01:28

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Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
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Dysrhythmias III: Characteristics of Dysrhythmias01:29

Dysrhythmias III: Characteristics of Dysrhythmias

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Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
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Related Experiment Video

Updated: Dec 11, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis.

Núria Farré1,2,3, Diana Mojón1, Marc Llagostera1

  • 1Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.

Journal of Clinical Medicine
|August 26, 2020
PubMed
Summary

A prolonged QT interval in patients with SARS-CoV-2 infection is linked to increased mortality. Early electrocardiogram screening can identify high-risk individuals for better outcomes.

Keywords:
COVID-19QT intervalazithromycindeathhydroxychloroquineprognosis

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The prognostic implications of a prolonged QT interval in patients with SARS-CoV-2 infection remain unclear.
  • Assessing the association between QT interval prolongation and patient outcomes is crucial for managing COVID-19.

Purpose of the Study:

  • To investigate whether a prolonged QT interval upon hospital admission independently predicts mortality in SARS-CoV-2 patients.
  • To establish the prognostic value of electrocardiogram findings in COVID-19.

Main Methods:

  • A single-center cohort study included 623 patients with confirmed SARS-CoV-2 infection.
  • Electrocardiograms were performed within 48 hours of diagnosis, prior to QT-altering medications.
  • Prolonged QT interval was defined as corrected QT (QTc) > 480 milliseconds; patients were followed until May 10, 2020.

Main Results:

  • 9.8% of patients exhibited a prolonged QTc interval.
  • Patients with prolonged QTc were older, had more comorbidities, and elevated immune-inflammatory markers.
  • Mortality was significantly higher in the prolonged QTc group (41.0% vs. 8.7%; adjusted HR 2.68; p < 0.001).

Conclusions:

  • A prolonged QTc interval on admission is an independent predictor of mortality in SARS-CoV-2 patients.
  • Electrocardiogram screening at admission can identify high-risk COVID-19 patients.
  • Findings suggest routine ECGs are valuable for risk stratification in SARS-CoV-2 infection.