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Updated: Dec 11, 2025

Targeted DNA Methylation Analysis by Next-generation Sequencing
Published on: February 24, 2015
Influence of quercetin on the global DNA methylation pattern in pigs
Gregor C Burdeos1, Ralf Blank1, Siegfried Wolffram1
1Institute of Animal Nutrition and Physiology, Christian-Albrechts-University Kiel, Hermann-Rodewald Str. 9, Kiel, Germany. burdeos@aninut.uni-kiel.de.
Abstract:
The plant flavonol quercetin causes multiple health-promoting effects in human and animals. In this study, we investigated the possible effects of quercetin on global DNA methylation in growing pigs after 7 weeks of feeding a quercetin-enriched diet. The results indicated that a trend for an improved feed conversion was observed in the quercetin fed group compared to the control group. Furthermore, quercetin influenced global DNA methylation by upregulating DNA methyltransferase 1 (DNMT1) in both mRNA and protein expressions in a tissue specific manner. The observed bioactivity of quercetin against the global methylation marker in pigs indicates that quercetin could be a potential inducer of DNA methylation which might be of economic significance for effective nutritional interventions affecting the health and productivity of animals.
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