Complement's favourite organelle-Mitochondria?

Area of Science:

• Immunology
• Cell Biology
• Metabolism

Background:

• The complement system is crucial for innate immunity.
• Emerging evidence highlights its cell-autonomous role in regulating cell physiology.
• The intracellular complement system, termed the complosome, impacts cell metabolism.

Purpose of the Study:

• To review the current knowledge on the complosome-mitochondria relationship.
• To discuss the role of the intracellular complement system in cell metabolism and homeostasis.
• To identify key questions in this novel research area.

Main Methods:

• Literature review of studies on intracellular complement.
• Analysis of the interaction between the complosome and mitochondria.
• Discussion of complement's role in immune cell function.

Main Results:

• The complosome controls key metabolic pathways within cells.
• Mitochondria have a significant and early relationship with the complosome.
• Intracellular complement components interact with other immune sensors like inflammasomes.

Conclusions:

• The intracellular complement system is a key regulator of cell metabolism and homeostasis.
• The complosome-mitochondria axis is central to understanding cell physiology and immunity.
• Further research is needed to elucidate the structure and function of intracellular complement.