Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Area of Science:

• Nanotechnology and Biosensing
• Infectious Disease Diagnostics

Background:

• The COVID-19 pandemic highlighted the urgent need for rapid, accessible diagnostic tools.
• Traditional methods like PCR and ELISA have limitations in speed and on-site application.
• Plasmonic-based biosensing emerges as a promising alternative for timely infectious disease monitoring.

Purpose of the Study:

• To review recent advancements in plasmonic sensing schemes for viral disease control.
• To focus on the application of plasmonic nanostructures in various detection formats.
• To assess the quantification of diverse viruses, with emphasis on SARS-CoV-2.

Main Methods:

• Compilation and review of recent literature on plasmonic sensing platforms.
• Analysis of plasmonic nanostructures integrated with colorimetric, fluorescence, luminescence, and Raman scattering techniques.
• Examination of sensor chip designs involving specific biomarkers and biological receptors.

Main Results:

• Plasmonic platforms offer on-site detection strategies complementing traditional assays.
• Integration with various detection formats enhances sensitivity and specificity for virus quantification.
• Review covers quantification of Hepatitis, Influenza, Norovirus, Dengue, Ebola, Zika, and SARS-CoV-2.

Conclusions:

• Plasmonic biosensing is crucial for managing infectious disease threats through rapid virus monitoring.
• Further research is needed to address technological limitations such as selectivity, stability, and biological matrix interference.
• Continued development of plasmonic sensing schemes will improve global public health preparedness.