Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmic
Layan El-Khatib1, Hussayn Alrayes2, Omar Sallam2
1Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA lelkha1@hfhs.org.
Abstract:
Quinidine is one of the oldest antiarrhythmics known. Over the years, its use has decreased along with its side effects. Our case describes a 69-year-old woman with recurrent resistant ventricular tachycardia on Quinidine and Amiodarone who presented with acute liver toxicity. Drug-induced liver toxicity was at the top of our differential diagnosis list. Taking multiple factors into consideration, a decision was made to discontinue Quinidine, the patient's symptoms and lab abnormalities resolved within 1 week, yielding the diagnosis of Quinidine hypersensitivity.
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