A Randomized Controlled Study to Compare Hemodynamic Effects between Clonidine and Pregabalin in Laparoscopic...

Area of Science:

• Anesthesiology
• Surgical Procedures
• Pharmacology

Background:

• Laparoscopic cholecystectomy (LC) involves pneumoperitoneum, leading to hemodynamic disturbances.
• Pregabalin and clonidine are explored for anesthetic effects and hemodynamic control during LC.
• Investigating optimal pharmacologic agents for stable hemodynamics in LC is crucial.

Purpose of the Study:

• To compare the efficacy of preoperative oral pregabalin and clonidine in maintaining hemodynamic parameters during LC.
• To assess the impact of these agents on heart rate and blood pressure.
• To evaluate the overall hemodynamic stability provided by pregabalin versus clonidine.

Main Methods:

• A prospective, randomized, single-blinded study involving 90 patients undergoing elective LC.
• Patients were divided into three groups receiving oral pregabalin (150 mg), clonidine (200 ug), or placebo.
• Hemodynamic parameters and adverse events were systematically recorded and analyzed.

Main Results:

• Both pregabalin and clonidine significantly attenuated the increase in heart rate and blood pressure during laryngoscopy and pneumoperitoneum compared to placebo.
• Clonidine group showed significantly lower heart rate post-extubation and in the postoperative period than pregabalin and control groups.
• No significant difference in the incidence of adverse events was observed between the groups.

Conclusions:

• Preoperative single oral doses of pregabalin (150 mg) and clonidine (200 ug) are effective in controlling hemodynamic parameters during LC.
• Clonidine provided superior hemodynamic stability compared to pregabalin during and after laparoscopic cholecystectomy.
• Both agents are viable options, with clonidine offering enhanced benefits for hemodynamic management.