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Updated: Dec 10, 2025
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
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Progression Low Squamous Intraepithelial Lesion and Human Papillomavirus Infections
Mahira Jahic1,2, Lejla Kameric2,3, Azra Hadzimehmedovic2,3
1Gynecology Centre "Dr Mahira Jahic" Tuzla, Tuzla, Bosnia and Herzegovina.
Materia Socio-Medica
|August 27, 2020
Summary
Human papillomavirus (HPV) type 16 is the most common cause of cervical lesions progressing to high-grade squamous intraepithelial lesions (HSIL). Women with HPV 16 require intensive monitoring due to increased cervical cancer risk.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Cervical carcinoma is primarily caused by human papillomavirus (HPV) infection.
- Bosnia and Herzegovina faces a significant burden with 556 annual cervical cancer diagnoses and 141 deaths.
Purpose of the Study:
- Identify the most prevalent HPV types in ASCUS and LSIL.
- Analyze the progression, regression, and persistence of cervical lesions.
- Determine the association between HPV types and lesion outcomes.
Main Methods:
- Retrospective analysis of 11,051 PAP tests from January 2016 to December 2019.
- Data collected from private gynecological practices in Tuzla Canton.
- Statistical analysis using the chi-squared (X²) method.
Main Results:
- Pathological findings were observed in 9.49% of PAP tests.
- HPV 16 was the most common type in ASCUS (50.5%) and LSIL cases.
- Lesions positive for HPV 16 showed a significantly higher progression rate to HSIL compared to low-risk HPV types (6 and 11).
Conclusions:
- HPV 16 infection is strongly associated with the progression of cervical lesions to HSIL.
- Intensive monitoring of women with HPV 16 is crucial for early detection and prevention of cervical cancer.
- Understanding HPV type prevalence aids in risk stratification and management of cervical dysplasia.
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