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Related Experiment Video

Updated: Dec 10, 2025

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Neck recurrence in papillary thyroid carcinoma.

RogÉrio Aparecido Dedivitis1, Leandro Luongo DE Matos2, AndrÉ Vicente GuimarÃes1

  • 1Irmandade da Santa Casa da Misericórdia de Santos, Santos, SP, Brazil.

Revista Do Colegio Brasileiro De Cirurgioes
|August 27, 2020
PubMed
Summary
This summary is machine-generated.

Papillary thyroid carcinoma patients with larger tumors face a significantly higher risk of neck recurrence. Tumor size is an independent risk factor, increasing recurrence risk by 2.4-fold per centimeter increase in diameter.

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Area of Science:

  • Oncology
  • Endocrinology
  • Surgical Oncology

Background:

  • Papillary thyroid carcinoma generally has a good prognosis.
  • However, a subset of patients experience neck recurrence after treatment.

Purpose of the Study:

  • To identify and evaluate risk factors associated with neck recurrence in papillary thyroid carcinoma patients.

Main Methods:

  • A retrospective study analyzed 89 patients with papillary thyroid carcinoma who underwent total thyroidectomy.
  • Data included patient demographics, initial diagnosis findings, and treatment details (neck dissection, radioiodinetherapy).
  • Statistical analyses, including Student t test, Fisher exact test, and logistic regression, were employed.

Main Results:

  • Tumor size was significantly larger in patients with cervical recurrence (3.3cm vs. 1.6cm, p=0.008).
  • The presence of metastatic lymph nodes at initial diagnosis was also a significant predictor of recurrence (p=0.004).
  • Multivariate analysis identified tumor size as an independent risk factor (OR=2.4, 95% CI: 1.3-4.6, p=0.007).

Conclusions:

  • Larger tumor size is a critical independent risk factor for neck recurrence in papillary thyroid carcinoma.
  • Each 1cm increase in the longest nodule diameter is associated with a 2.4-fold increased risk of lymph node recurrence.