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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Pregnancy Outcomes in Systemic Vasculitides
Carolyn Ross1, Rohan D'Souza2, Christian Pagnoux3
1Vasculitis Clinic, Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Pregnancy in women with vasculitis is increasingly common. While successful pregnancies are possible with planned conception during remission, careful monitoring by a multidisciplinary team is crucial for managing risks and optimizing outcomes.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Improved survival in vasculitis patients leads to more pregnancies.
- Pregnancy in women with vasculitis requires specialized care.
Purpose of the Study:
- Review the impact of pregnancy on vasculitis activity.
- Summarize maternal and fetal outcomes in pregnant vasculitis patients.
- Analyze outcomes by vasculitis type.
Main Methods:
- Literature review of pregnancy outcomes in vasculitis.
- Synthesis of data on disease activity, maternal, and fetal complications.
Main Results:
- Successful pregnancy is achievable, especially in remission.
- Large-vessel vasculitis risks include hypertension and preeclampsia.
- Small- and medium-vessel vasculitis are linked to preterm birth and growth restriction.
- Pregnancies are high-risk, requiring multidisciplinary management.
- Flare management should avoid teratogenic medications.
Conclusions:
- Pregnancy in vasculitis is feasible but high-risk.
- Multidisciplinary care and careful medication management are essential.
- Further research is needed on aspirin, biologics, and outcome predictors.
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