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Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro
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Controlling stem cell fate using cold atmospheric plasma.

Fei Tan1,2,3, Yin Fang4, Liwei Zhu5

  • 1Department of ORL-HNS, Affiliated East Hospital of Tongji University, Shanghai, China. iatrologist@163.com.

Stem Cell Research & Therapy
|August 28, 2020
PubMed
Summary
This summary is machine-generated.

Cold atmospheric plasma (CAP) offers versatile methods to regulate stem cell fate for regenerative medicine. This review explores direct and indirect CAP applications, focusing on mechanisms influencing healthy and cancer stem cells.

Keywords:
Atmospheric plasmaCell attachmentCell deathCell differentiationCell proliferationCold plasmaExtracellular matrixNon-thermal plasmaPlasma medicinePlasma-activated mediumRegenerative medicineScaffoldStem cellStem cell nicheSurface modificationTissue engineering

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Area of Science:

  • Plasma Medicine
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cells are crucial for regenerative medicine and tissue engineering.
  • Controlling stem cell fate (attachment, proliferation, differentiation, death) is a key area of research.
  • Cold atmospheric plasma (CAP) is a promising technology for manipulating cell behavior.

Purpose of the Study:

  • To review recent advances in direct and indirect CAP strategies for controlling stem cell fate.
  • To examine the influence of CAP on both healthy and cancer stem cells.
  • To elucidate the mechanisms linking plasma-derived cues to cellular responses at the transcriptomic level.

Main Methods:

  • Review of existing literature on CAP applications in stem cell research.
  • Analysis of studies employing direct CAP irradiation of stem cells.
  • Examination of research on indirect CAP applications, including stem cell niche modification.

Main Results:

  • CAP can directly influence stem cell fate through physical and chemical interactions.
  • Indirect CAP application via niche modification also effectively regulates stem cell behavior.
  • Transcriptomic analysis reveals molecular mechanisms underlying CAP's effects on stem cells.

Conclusions:

  • CAP presents a versatile platform for modulating stem cell fate in regenerative medicine.
  • Understanding CAP-cell interaction mechanisms is vital for therapeutic applications.
  • CAP holds significant potential for advancing regenerative medicine and cancer therapy.