Related Experiment Video
Updated: Dec 10, 2025

Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro
Published on: January 11, 2019
Controlling stem cell fate using cold atmospheric plasma
Fei Tan1,2,3, Yin Fang4, Liwei Zhu5
1Department of ORL-HNS, Affiliated East Hospital of Tongji University, Shanghai, China. iatrologist@163.com.
Abstract:
The stem cell is the foundation of regenerative medicine and tissue engineering. Regulating specific stem cell fate, such as cell attachment, proliferation, differentiation, and even death, undergoes continuous development. Cold atmospheric plasma (CAP), the core technology of plasma medicine, is attracting tremendous attention due to its ability and versatility to manipulate various types of cells, including stem cells. Specifically, the direct and indirect applications of CAP in controlling cell fate are best exemplified by upfront irradiation of the stem cells and modification of the stem cell niche, respectively. This review will describe the recent advances in various CAP strategies, both direct and indirect, and their influence on the fate of healthy and cancer stem cells. Particular emphasis will be placed on the mechanism of connecting the physical and chemical cues carried by the plasma and biological changes presented by the cells, especially at the transcriptomic level. The ultimate goal is to exploit CAP's potential in regenerative medicine.
More Related Videos
Related Concept Videos
Stem Cell Culture
Maintenance of the ES Cell State
Somatic to iPS Cell Reprogramming
Methods of Nuclear Reprogramming
Lineage Commitment

