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Related Experiment Video

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Analysis of Schwann-astrocyte Interactions Using In Vitro Assays
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FGF5 Regulates Schwann Cell Migration and Adhesion.

Bing Chen1, Rong Hu2, Qing Min3

  • 1Department of Neurology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, China.

Frontiers in Cellular Neuroscience
|August 28, 2020
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 5 (FGF5) is upregulated in peripheral nerve injury. FGF5 promotes Schwann cell migration and adhesion, suggesting an autocrine role in nerve repair.

Keywords:
FGF5N-cadherinSchwann celladhesionmigrationperipheral nerve injuryreceptors

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • Fibroblast growth factors (FGFs) are crucial for tissue repair.
  • FGF5 is upregulated in Schwann cells after peripheral nerve injury.
  • Its specific role in nerve regeneration remains unclear.

Purpose of the Study:

  • To investigate FGF5 expression and its receptors in injured sciatic nerves.
  • To determine the functional effects of FGF5 on primary Schwann cells.

Main Methods:

  • Microarray and mRNA sequencing
  • RT-PCR and qPCR
  • Western blotting and immunostaining
  • Primary rat Schwann cell culture and treatment

Main Results:

  • FGF5 is highly upregulated in mouse distal sciatic nerve Schwann cells post-injury.
  • FGFR1 and FGFR2 are expressed in Schwann cells before and after injury.
  • FGF5 inhibits ERK1/2 MAP kinase activity.
  • FGF5 promotes Schwann cell migration and adhesion via N-cadherin upregulation.

Conclusions:

  • FGF5 is an autocrine regulator of Schwann cell migration and adhesion.
  • FGF5 plays a significant role in peripheral nerve regeneration.