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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging
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Get in Touch With Dendritic Epithelial T Cells!

Flavian Thelen1, Deborah A Witherden1

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.

Frontiers in Immunology
|August 28, 2020
PubMed
Summary
This summary is machine-generated.

Dendritic epidermal T cells (DETC), a type of γδT cell, are crucial for skin immunity. This review highlights how cell-cell interactions shape DETC function in skin homeostasis and immune responses.

Keywords:
DETCactivationcostimulationepidermisepithelialγδT cell

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Innate and adaptive immunity are interconnected for host defense.
  • γδT cells bridge innate and adaptive immunity.
  • Dendritic epidermal T cells (DETC) are specialized γδT cells in the skin.

Purpose of the Study:

  • To review the underappreciated functions of DETC and other γδT cells in the skin.
  • To discuss the development and function of DETC in skin homeostasis and immunity.
  • To highlight recent advances in understanding γδT cell roles in skin.

Main Methods:

  • Review of existing literature and recent discoveries.
  • Focus on cellular imaging advancements for studying cell interactions.
  • Discussion of developmental pathways and cell-cell interactions.

Main Results:

  • DETC possess unique morphology for extensive epidermal interactions.
  • Cell-cell interactions are vital for DETC formation, activation, and maintenance.
  • DETC play significant roles in skin homeostasis and immune responses.

Conclusions:

  • DETC are critical immune sentinels in the skin.
  • Understanding DETC-keratinocyte and DETC-Langerhans cell interactions is key to skin immunity.
  • γδT cells, particularly DETC, are important in both human and mouse skin immunity.