Related Experiment Video
Updated: Dec 10, 2025
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
A Controllable Inflammatory Response and Temporary Abnormal Coagulation in Moderate Disease of COVID-19 in Wuhan,
Yuchen Liu1,2, Xiaohong Zhang3,2, Jialu Qiao1
1Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Insights
This study analyzed laboratory findings in moderate COVID-19 patients in Wuhan, finding controllable inflammation. Older patients (over 60) showed higher inflammatory markers and slower coagulation recovery, necessitating closer monitoring.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Epidemiology
Background:
- Coronavirus disease 2019 (COVID-19) presents a global public health challenge.
- While most COVID-19 cases are mild to moderate, research on these patients remains limited.
- This study focuses on characterizing laboratory markers in moderate COVID-19 cases during Wuhan's initial pandemic wave.
Purpose of the Study:
- To clarify the laboratory test characteristics of COVID-19 patients with moderate symptoms.
- To analyze demographic and clinical data of moderate COVID-19 cases.
- To compare laboratory findings between different age groups (young, middle-aged, elderly).
Main Methods:
- Retrospective cohort study of 107 adult inpatients with moderate COVID-19.
- Data collected from February to early March 2020 at the Affiliated Hospital of Jianghan University.
- Analysis of demographic, clinical, and laboratory data at admission and discharge using SPSS.
Main Results:
- Median age was 56.0 years, with a median hospitalization of 16 days.
- Common symptoms included fever, cough, asthenia, and shortness of breath.
- Admission labs revealed elevated neutrophils, low lymphocytes, decreased hemoglobin, and increased inflammatory markers (ESR, CRP); some had coagulation/myocardial issues.
- Patients >60 years had higher CRP, ESR, and fibrinogen.
- At discharge, most labs normalized, except hemoglobin, blood cell counts, and ESR.
- Older patients exhibited slower recovery of coagulation parameters.
Conclusions:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in moderate COVID-19 patients induces a manageable inflammatory response.
- Older patients (>60 years) present with heightened inflammation and more disordered coagulation.
- Close monitoring of elderly patients with moderate COVID-19 is crucial due to their inflammatory and coagulation profiles.
Background:
The coronavirus disease 2019 (COVID-19) is now a worldwide challenge for public health. Among 7 million patients, about 80% present mild to moderate disease, but studies dedicate to these patients are actually scarce. The aim of our study is to clarify the characteristics of laboratory test index of COVID-19 patient with moderate symptoms during the first wave of the pandemic in Wuhan, China.
Methods:
In this retrospective cohort study, we included 107 adult inpatients with confirmed moderate disease of COVID-19 from the Affiliated Hospital of Jianghan University during February and early March 2020. All of these patients were recovered from COVID-19 and discharged from hospital. Demographic, clinical, and laboratory data of admission and discharge were extracted from electronic medical records and analyzed using SPSS, as well as among young, middle age and elderly people.
Results:
The median age of this cohort of patients was 56.0 years. And the median hospitalization time was 16 days. Common clinical manifestations included fever, cough, asthenia and shortness of breath. On admission, laboratory results showed normal or increased neutrophil ratio, low lymphocyte count, decreased hemoglobin level, and increased inflammatory indicators (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)); and some patients were complicated with coagulation disorder and myocardial damage. Furthermore, patients older than 60 years had statistically higher CRP, ESR and fibrinogen level. As the health condition was improved at discharge, the median level of most laboratory results were in the normal range except hemoglobin and related blood cell count, as well as inflammatory indicator ESR. And patients older than 60 years showed slower recovery on coagulation parameters when compared to younger patients.
Conclusions:
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a controllable inflammatory response in moderate disease of COVID-19 in Wuhan, China. Since patients older than 60 years had higher inflammatory state and more dysregulated coagulation condition, it might be essential to closely assess their illness.
Related Concept Videos
01:13Controls in Experiments
01:30Inflammatory Response I: Vascular and Cellular
01:28Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:29Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...