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A Study for Expanding Application Sites for Rotigotine Transdermal Patch.

Hitoshi Kujirai1,2, Sakiko Itaya1, Yumi Ono3

  • 1Department of Neurology, Kanto Central Hospital, Tokyo 158-8531, Japan.

Parkinson'S Disease
|August 28, 2020
PubMed
Summary

The rotigotine transdermal patch (RTP) may be applied to the shin to reduce skin reactions in Parkinson's disease (PD) patients. This alternative site showed fewer skin issues and improved motor symptoms compared to approved locations.

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Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Rotigotine transdermal patch (RTP) is a dopamine agonist for Parkinson's disease (PD).
  • Application site reactions (ASRs) can limit RTP treatment adherence in PD patients.
  • Investigating alternative application sites for RTP is crucial for improving patient compliance.

Purpose of the Study:

  • To evaluate the safety and efficacy of applying RTP to the shin.
  • To compare skin reactions and symptom control between approved sites and the shin.
  • To assess the impact of shin application on motor symptoms and plasma rotigotine levels.

Main Methods:

  • A study involving 30 PD patients experiencing ASRs with RTP.
  • Patients applied RTP to approved sites for 4 weeks (pre-RTP) then to the shin for 4 weeks (post-RTP).
  • Evaluated skin reactions (visual analogue scale, skin irritation score), motor symptoms (MDS-UPDRS Part III), and plasma rotigotine concentration.

Main Results:

  • Significantly lower visual analogue scale and skin irritation scores on the shin compared to approved sites.
  • Slight but significant improvement in MDS-UPDRS Part III scores when applying RTP to the shin.
  • Slightly lower plasma rotigotine concentration observed with shin application.

Conclusions:

  • The shin is a viable alternative application site for the rotigotine transdermal patch.
  • Shin application of RTP can reduce skin reactions and potentially improve motor symptoms in PD patients.
  • Further research may confirm the shin as a beneficial site for long-term RTP therapy.