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Updated: Dec 10, 2025

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
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Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering.

Pilar Montero1, María Flandes-Iparraguirre1, Saioa Musquiz1,2

  • 1Regenerative Medicine Program, Cima Universidad de Navarra, Foundation for Applied Medical Research, Pamplona, Spain.

Frontiers in Bioengineering and Biotechnology
|August 28, 2020
PubMed
Summary

Regenerative therapies aim to repair hearts damaged by myocardial infarction (MI), a leading cause of death. This review explores engineered cardiac tissues using stem cells and advanced manufacturing for heart repair and clinical translation.

Keywords:
cardiac tissue engineeringcell differentiationfabrication strategieshuman pluripotent stem cellsmaterial properties

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Cardiovascular disease, particularly myocardial infarction (MI), is a leading global cause of mortality.
  • MI leads to progressive heart damage due to limited regenerative capacity and pathological remodeling.
  • Current pharmacological treatments are insufficient to halt MI progression.

Purpose of the Study:

  • To review the generation of human cardiac tissues for therapeutic applications.
  • To highlight advances in regenerative medicine for treating myocardial infarction.
  • To discuss cellular processes, materials, and fabrication strategies in cardiac tissue engineering.

Main Methods:

  • Focus on human pluripotent stem cells and their derivatives for cardiac tissue generation.
  • Review of tissue engineering principles for mimicking cardiac 3D structure and function.
  • Examination of recent advances in cell reprogramming and additive manufacturing.

Main Results:

  • Progress from early cell therapy to current engineered cardiovascular tissues.
  • Overview of ongoing research in cellular processes, biomaterials, and fabrication methods.
  • Summary of current clinical applications and future research needs.

Conclusions:

  • Engineered cardiac tissues hold promise for treating MI.
  • Human pluripotent stem cells are key to developing therapeutic cardiac tissues.
  • Further research is needed to bridge the gap between laboratory findings and clinical application.