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Two new 13-hydroxylated milbemycin metabolites from the genetically engineered strain Streptomyces avermitilis
Ji-Dong Wang1, Huan Qi1, Ji Zhang2
1Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China.
Abstract:
Two new milbemycin metabolites, 13α-hydroxymilbemycin β13 (1) and 26-methyl-13α-hydroxymilbemycin β13 (2), were isolated from the fermentation broth of a genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were determined by the comprehensive spectroscopic data, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. Compounds 1 and 2 not only exhibited potent acaricidal activities against Tetranychus cinnabarinus, but also had nematocidal activity against Bursaphelenchus xylophilus.
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