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[Consequences of Gout and Hyperuricemia]

Mats Dehlin1, Meliha Kapetanovic1, Anna Svärd2

  • 1.

Lakartidningen
|August 28, 2020
PubMed

Insights

Hyperuricemia (HU) and gout are linked to cardiovascular disease (CVD) due to shared causes like obesity and metabolic syndrome. Gout is treatable with urate-lowering therapy (ULT), potentially improving associated conditions.

Area of Science:

  • Cardiovascular Science
  • Nephrology
  • Neurology

Background:

  • Hyperuricemia (HU) and gout exhibit strong associations with cardiovascular disease (CVD), likely stemming from shared underlying etiologies.
  • HU is causally linked to metabolic syndrome, obesity, and can contribute to or result from impaired kidney function.
  • Observational studies suggest potential protective effects of HU against neurodegenerative conditions like Alzheimer's and Parkinson's disease.

Purpose of the Study:

  • To explore the complex relationship between hyperuricemia, gout, and associated comorbidities.
  • To discuss the role of urate-lowering therapy (ULT) in managing gout and its impact on related health issues.
  • To address existing controversies regarding HU's influence on cardiovascular and neurodegenerative diseases.

Main Methods:

  • Review of existing literature on hyperuricemia, gout, and their associations with cardiovascular and neurodegenerative diseases.
  • Analysis of observational data and ongoing randomized controlled trials (RCTs) concerning urate and ULT.
  • Discussion of the etiological links between HU, metabolic syndrome, obesity, and kidney function.

Main Results:

  • The association between HU/gout and CVD is likely multifactorial, involving shared risk factors rather than direct causality.
  • HU and gout can negatively impact kidney function, while also being influenced by renal health.
  • Emerging evidence suggests a potential neuroprotective role for HU in certain neurodegenerative diseases, though further research is needed.
  • Ongoing RCTs are crucial for clarifying the causal relationships and therapeutic potential of ULT.

Conclusions:

  • Gout is a curable condition with urate-lowering therapy (ULT).
  • Adequate ULT may offer benefits for comorbidities associated with gout and hyperuricemia.
  • Further research, including RCTs, is essential to fully understand the multifaceted roles of urate in health and disease.

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