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Updated: Dec 10, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Naturally Occurring seco-Sativene Sesquiterpenoid: Chemistry and Biology
Yuan-Yuan Li1, Xiang-Mei Tan1, Jian Yang2
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Abstract:
seco-Sativenes are a small group of sesquiterpenoids with a unique bicyclo[3.2.1]octane core carbon skeleton, which implies the unusual biosynthetic pathway. Up to date, there are 40 seco-sativene analogues with diverse post-modifications isolated from different fungi. Interestingly, some seco-sativene analogues display strong phytotoxic effects, whereas others possess plant-growth-promoting biological activities. The possible mechanism of actions about phytotoxic or growth-promoting activities are partly elucidated, but structure-activity relationships are still not clear. This review provides a comprehensive overview on the structures, 1H nuclear magnetic resonance features, bioactivities, and biosynthesis of seco-sativene sesquiterpenoids from 1956 to 2020.
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