Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances

Area of Science:

• Marine biology
• Pharmacology
• Cardiovascular research

Background:

• Atherosclerosis involves arterial wall lipid accumulation and inflammation, underlying major cardiovascular diseases.
• Current treatments for slowing atherosclerosis progression are limited and costly.
• Marine organisms are a rich source for novel therapeutic drug development.

Purpose of the Study:

• To review recent advances in marine-derived anti-atherosclerotic substances.
• To explore the structures, mechanisms of action, and therapeutic potential of these compounds.
• To discuss challenges in applying marine-derived substances for atherosclerosis treatment.

Main Methods:

• Literature review of marine-derived compounds with anti-atherosclerotic properties.
• Analysis of structures and mechanisms of action of marine polysaccharides, proteins, peptides, PUFAs, and small molecules.
• Examination of theoretical basis for marine biological resources in atherosclerosis treatment.

Main Results:

• Marine-derived substances, including polysaccharides, proteins, peptides, polyunsaturated fatty acids, and small molecules, show potential against atherosclerosis.
• Understanding the structures and mechanisms of action is key to developing effective marine-based therapies.
• Challenges remain in the application and development of these marine resources.

Conclusions:

• Marine biological resources provide a strong theoretical foundation for developing novel, cost-effective anti-atherosclerotic drugs.
• Further research into marine-derived compounds can lead to new therapeutic strategies for cardiovascular diseases.
• Overcoming application challenges will unlock the full potential of marine natural products in medicine.