Beyond the mechanical lens: Systemic inflammatory responses to repetitive lifting under varying loads and frequencies

Currently, low back disorder (LBD) research focuses primarily on mechanical variables to assess whether task demands exceed tissue capacity; however, it is important to assess how other nonmechanical variables affect tissue capacity in a time-dependent manner. The current investigation sought to explore physiological responses to an acute lifting task, as lifting has been implicated as a risk factor in the development of LBDs.

Twelve participants completed two sessions of 2 h of repetitive symmetrical lifting from floor to knuckle height under two conditions, matched for total external work (Low Force High Repetition (LFHR) and High Force Low Repetition (HFLR)). Full-body kinematics and ground reaction forces were measured throughout. Interleukin 6 (IL-6) and interleukin 8 (IL-8), markers of systemic inflammation, were assessed from blood sampling at Baseline, 0, 4 and 24 h post-lifting on both days. Dual x-ray absorptiometry (DEXA) scans were also performed on participants to quantify body composition.

Significant load (HFLR and LFHR) * time (Baseline, 0, 4, 24 h) interaction effects were found for both IL-6 and IL-8, where the LFHR condition resulted in greater responses at 0 and 4 h post-lifting.

This was the first study of its kind to concurrently measure peak and cumulative spinal moments and their relationship to systemic inflammation in both sexes, while strictly controlling for confounding variables (e.g. physical activity, caloric intake, body composition, etc.). Greater levels of IL-6 and IL-8 were seen in the LFHR condition, likely due to the greater cumulative spinal moments in this condition.