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Regen med therapeutic opportunities for fighting COVID-19

Anthony Atala1, Alicia Henn2, Martha Lundberg3

  • 1Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA.

Stem Cells Translational Medicine
|August 29, 2020
PubMed

Insights

Regenerative medicine offers novel therapeutic strategies against COVID-19 by exploring unique viral mechanisms and utilizing advanced models. This approach aims to accelerate drug discovery and patient identification for better pandemic response.

Area of Science:

  • Regenerative Medicine
  • Virology
  • Drug Discovery

Background:

  • SARS-CoV-2 presents unique challenges compared to other viruses.
  • The COVID-19 pandemic necessitates innovative therapeutic approaches.
  • Regenerative medicine manufacturing offers potential solutions.

Purpose of the Study:

  • To highlight regenerative medicine's therapeutic opportunities for COVID-19.
  • To explain the unique characteristics of SARS-CoV-2.
  • To review current and future regenerative medicine strategies for COVID-19 treatment.

Main Methods:

  • Discussion of animal models to elucidate COVID-19 mechanisms of action.
  • Exploration of organoid platforms for drug screening and patient stratification.
  • Critical evaluation of promising regenerative medicine-based therapies.

Main Results:

  • Animal models can help identify potential treatments for COVID-19.
  • Organoid platforms show promise for rapid drug screening and identifying at-risk individuals.
  • Regenerative medicine technologies offer a collective resource for pandemic response.

Conclusions:

  • Regenerative medicine provides a powerful framework for developing novel COVID-19 therapies.
  • Advanced models like organoids are crucial for accelerating research and treatment.
  • Collaboration and utilization of existing technologies are key to combating the pandemic.
Keywords:
COVID-19SARS-CoV-2animal modelsmesenchymal stromal/stem cellsorganoidsregenerative medicine

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