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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Automated vessel diameter quantification and vessel tracing for OCT angiography.

Wei Wei1, Qinqin Zhang1, Samuel G Rayner1,2

  • 1Department of Bioengineering, University of Washington, Seattle, Washington, USA.

Journal of Biophotonics
|August 29, 2020
PubMed
Summary

We developed automated methods using Optical Coherence Tomography Angiography (OCTA) to map individual capillaries and analyze vascular networks. This technique improves accuracy for diagnosing vascular diseases by detecting early morphological changes.

Keywords:
GUI analysis platformOCTOCT angiographybranching anglephantom validationvasculature quantificationvessel diametervessel tortuosityvessel tracing

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Ophthalmology

Background:

  • Optical coherence tomography angiography (OCTA) enables non-invasive in vivo imaging of vascular networks.
  • Advancements in OCTA image quality allow for extraction of vascular parameters for disease diagnosis and treatment.

Purpose of the Study:

  • To present an automated method for mapping vessel diameter down to the capillary level using OCTA.
  • To validate the technique in vitro and in vivo for enhanced vascular analysis.

Main Methods:

  • Gradient-guided minimum radial distance (MRD) for automated vessel diameter mapping.
  • Modified A* path searching algorithm for tracing vessel branches and calculating diameters.
  • Validation using microfluidic flow phantoms and in vivo mouse cortical vasculature.

Main Results:

  • MRD method showed superior consistency and reduced error compared to existing techniques.
  • The algorithm successfully traced vessel branches and calculated diameters, adhering to Murray's law down to the capillary level.
  • Vessel tortuosity and branching angles were measurable, aligning with physiological data.

Conclusions:

  • The developed automated techniques provide a platform for comprehensive vascular evaluation using OCTA.
  • This method may aid in the early diagnosis of vascular diseases, particularly those with subtle morphological changes.