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[Verapamil versus propranolol in stable effort angina. Randomized, crossed, double-blind study]
J P Lesbre1, J D Lalau, M L Jaubourg
1Service de Cardiologie B, Hôpital Sud, Amiens.
Annales De Cardiologie Et D'Angeiologie
|April 1, 1988
Summary
Both verapamil and propranolol improved exercise duration and reduced ST segment depression in patients with stable effort angina compared to placebo. Verapamil also decreased resting diastolic blood pressure, while propranolol significantly lowered resting heart rate.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Stable effort angina is a common manifestation of coronary heart disease.
- Pharmacological interventions aim to improve exercise tolerance and reduce ischemic events.
Purpose of the Study:
- To compare the efficacy of verapamil and propranolol in patients with stable effort angina.
- To assess the effects of these drugs on exercise capacity and hemodynamic parameters.
Main Methods:
- A randomized, crossover, double-blind study involving 16 coronary patients.
- Patients received verapamil (360 mg), propranolol (120 mg), or placebo for 3-day periods.
- Therapeutic efficacy was evaluated using treadmill stress testing (Bruce protocol) and automated analysis.
Main Results:
- Both verapamil and propranolol significantly increased stress test duration and decreased ST segment depression compared to placebo.
- Propranolol significantly reduced resting heart rate and systolic blood pressure at maximum effort.
- Verapamil significantly reduced resting systolic and diastolic blood pressure and diastolic blood pressure on exertion.
Conclusions:
- Verapamil and propranolol are effective in improving exercise capacity and reducing myocardial ischemia in stable effort angina.
- Each drug exhibits distinct effects on heart rate and blood pressure regulation.