Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

4.2K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
4.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

116
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
116
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

2.6K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
2.6K
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

87
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
87
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

109
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
109

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Sreedharan et al. The Neuroprotective Effects of <i>Oroxylum indicum</i> Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression Under LPS Induced Inflammation. <i>Nutrients</i> 2024, <i>16</i>, 1887.

Nutrients·2026
Same author

<i>Equisetum hyemale</i> L. Extracts: Phytochemistry, Biological Performance, ADMET Profiling, and Toxicity Predictions.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Synthetic Mimics of Wound-Induced Carrot MicroRNAs Affect Lipid Metabolism in Cultured Adipocytes.

Nutrients·2025
Same author

Ferulic Acid: Mechanistic Insights and Multifaceted Applications in Metabolic Syndrome, Food Preservation, and Cosmetics.

Molecules (Basel, Switzerland)·2025
Same author

Tailoring Biopesticides: Amphiphile-Assisted Nanoprecipitation of Azadirachtin within a Glycine Matrix for Sustainable Agriculture, Enhanced Stability, and Larvicidal Efficacy against Fall Armyworm.

ACS omega·2025
Same author

Organosilanized Hydrophobic Sand for Drought Resilience: Reducing Water Percolation and Enhancing Crop Growth Conditions.

ACS omega·2025

Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
07:05

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

2.5K

Bioactive Phenolics and Polyphenols: Current Advances and Future Trends.

Daniel A Jacobo-Velázquez1, Luis Cisneros-Zevallos2

  • 1Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey NL C.P. 64849, Mexico.

International Journal of Molecular Sciences
|August 30, 2020
PubMed
Summary

Phenolic compounds, found in plants, offer significant health benefits due to their antioxidant and anti-inflammatory effects. Further research explores their therapeutic potential in various health conditions.

More Related Videos

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.2K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.6K

Related Experiment Videos

Last Updated: Dec 10, 2025

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
07:05

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

2.5K
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.2K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.6K

Area of Science:

  • Biochemistry
  • Phytochemistry
  • Nutraceuticals

Background:

  • Phenolic compounds are diverse secondary plant metabolites.
  • They exhibit potent antioxidant and anti-inflammatory activities.
  • These properties contribute to numerous health-promoting effects.

Discussion:

  • The biological activities of phenolic compounds are linked to their chemical structure.
  • Their bioavailability and metabolism influence their efficacy.
  • Synergistic effects with other nutrients are being investigated.

Key Insights:

  • Phenolic compounds demonstrate significant potential in preventing chronic diseases.
  • Specific phenolic compounds show promise in managing conditions like cardiovascular disease and certain cancers.
  • Dietary intake of phenolic-rich foods is associated with improved health outcomes.

Outlook:

  • Future research will focus on isolating and synthesizing specific phenolic compounds for targeted therapeutic applications.
  • Investigating the mechanisms of action and optimizing delivery systems are key areas for development.
  • Exploring the role of phenolic compounds in personalized nutrition and disease prevention strategies.