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Updated: Dec 10, 2025

Molecular Imaging of Human Brain Organoids Using Mass Spectrometry
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Quo Vadis, Molecular Imaging?

Jan Grimm1, Fabian Kiessling2, Bernd J Pichler3

  • 1Molecular Pharmacology Program and Department of Radiology, Memorial Sloan Kettering Cancer Center, and Pharmacology Program and Department of Radiology, Weil Cornell Medical College, New York, New York grimmj@mskcc.org.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 30, 2020
PubMed
Summary
This summary is machine-generated.

Molecular imaging (MI) offers unique insights into biologic signatures, bridging preclinical and clinical research. This perspective explores MI

Keywords:
diagnostic probemolecular imagingmultiparametric imagingradiomicsradiotracer

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Area of Science:

  • Medical Imaging
  • Biotechnology
  • Translational Research

Background:

  • Molecular imaging (MI) provides insights into biologic signatures beyond conventional methods, linking preclinical and clinical research.
  • MI research yields new diagnostic probes and imaging methods with clinical applications.
  • Concerns exist regarding MI's added value compared to less expensive conventional imaging.

Purpose of the Study:

  • To discuss seminal research directions in molecular imaging with potential patient benefit.
  • To highlight emerging clinical indications and technical innovations in MI.
  • To emphasize the added value of MI over conventional diagnostic methods.

Main Methods:

  • Perspective discussion of key research areas in molecular imaging.
  • Focus on MI without probes, radiotracer-based MI, and nano/microsystems.
  • Integration of MI with comprehensive diagnostics and emerging clinical applications.

Main Results:

  • Identified key research directions for MI with potential patient value.
  • Highlighted innovations in probes, MI systems, and diagnostic integration.
  • Emphasized emerging clinical applications for molecular imaging.

Conclusions:

  • Molecular imaging research offers significant potential for patient benefit.
  • Continued innovation in MI probes, systems, and applications is crucial.
  • MI's added value needs to be clearly demonstrated against conventional methods.