Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.9K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.5K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.5K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.3K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.3K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.2K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.2K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.2K
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global research trends of cell death in diabetic cardiomyopathy from 2000 to 2024: a bibliometric analysis and integrative overview.

Journal of cardiothoracic surgery·2026
Same author

Deep-Ultraviolet Transparent Zr/Hf Fluorides with Second-Harmonic Generation Effects Induced by Alkali-Metal Modulation.

Inorganic chemistry·2026
Same author

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells.

bioRxiv : the preprint server for biology·2026
Same author

Epidemiological characteristics of Echinococcus granulosus infection in children from some sites in Xinjiang and its association with platelets.

BMC infectious diseases·2026
Same author

An anionic cyanine probe with enhanced ROS-stability for butylcholinesterase detection in non-alcoholic fatty liver disease.

Chemical communications (Cambridge, England)·2026
Same author

An Organelle-Orthogonal Dual-Response Probe for In Situ Monitoring of Mitochondrial H<sub>2</sub>O<sub>2</sub> and Lipid Droplet Polarity in Ferroptosis.

Analytical chemistry·2026
Same journal

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

MHC class II on melanoma cells regulates the anti-tumor T cell response.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

ER stress amplifies inflammation via a dual mechanism involving IκBζ-XBP1s synergism and Regnase-1 degradation.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance.

Journal of immunology (Baltimore, Md. : 1950)·2026
See all related articles

Related Experiment Video

Updated: Dec 10, 2025

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

16.6K

B Cell αv Integrins Regulate TLR-Driven Autoimmunity.

Mridu Acharya1,2, Fiona Raso3, Sara Sagadiev3,2

  • 1Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101; macharya@benaroyaresearch.org adamlh@benaroyaresearch.org.

Journal of Immunology (Baltimore, Md. : 1950)
|August 30, 2020
PubMed
Summary
This summary is machine-generated.

Alpha-v (αv) integrin regulates B cell signaling to self-antigens, preventing systemic lupus erythematosus (SLE). Loss of αv accelerates autoantibody production and autoimmune kidney disease in mice, highlighting a new pathway in autoimmunity.

More Related Videos

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.4K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

3.0K

Related Experiment Videos

Last Updated: Dec 10, 2025

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

16.6K
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.4K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

3.0K

Area of Science:

  • Immunology
  • Molecular Biology
  • Autoimmunity

Background:

  • Systemic lupus erythematosus (SLE) involves loss of B cell tolerance and autoantibody production.
  • Aberrant Toll-like receptor (TLR) activation by self-nucleic acids is linked to SLE.
  • Mechanisms regulating TLR signaling to self-ligands in SLE are not fully understood.

Purpose of the Study:

  • To investigate the role of αv integrin in regulating B cell TLR signaling to self-antigens.
  • To determine the impact of αv deletion in B cells on SLE development in a mouse model.

Main Methods:

  • Utilized a Tlr7.1 transgenic mouse model of SLE.
  • Generated mice with αv deletion specifically in B cells.
  • Analyzed autoantibody production, kidney disease, B cell populations, and T cell activation.

Main Results:

  • Deletion of αv from B cells accelerated autoantibody production and autoimmune kidney disease.
  • Increased autoimmunity correlated with expanded transitional B cells and extrafollicular IgG2c plasma cells.
  • CD4 and CD8 T cell activation was observed in αv-deficient B cells.

Conclusions:

  • αv integrin is critical for regulating B cell TLR signaling to self-antigens in mice.
  • Loss of αv promotes escape from B cell tolerance, contributing to autoimmunity.
  • Identified a novel regulatory pathway involving αv integrin in preventing SLE development.