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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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A pilot study on pattern B lipoprotein profile in Malaysia.

C S Thambiah1, N A Mohamed Pesri, N Mazalan

  • 1Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, Selangor Darul Ehsan, Malaysia. subashini@upm.edu.my.

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|August 30, 2020
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A high prevalence of Pattern B, a cardiovascular disease risk factor, was found in Malaysia, particularly in Chinese males with dyslipidemia and higher BMI. This highlights individuals with normal lipid levels but atherogenic patterns are at increased risk.

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Area of Science:

  • Cardiovascular Health
  • Lipid Metabolism
  • Public Health

Background:

  • Dyslipidemia is a key cardiovascular disease (CVD) risk factor.
  • Elevated CVD risk persists even with normal traditional lipid parameters.
  • Small dense low-density lipoprotein cholesterol (sdLDL) is a significant CVD risk marker.

Purpose of the Study:

  • Determine the prevalence of atherogenic lipoprotein Pattern B in Malaysia.
  • Identify factors associated with Pattern B in the Malaysian population.

Main Methods:

  • Cross-sectional study of 150 Malaysian adults (≥30 years).
  • Collected sociodemographic, clinical, and laboratory data (lipids, glucose, sdLDL).
  • Analyzed lipoprotein subfractions using polyacrylamide gel electrophoresis.

Main Results:

  • Prevalence of Pattern B was 33%, with 6.7% being normolipidaemic.
  • Pattern B was more common in women (p=0.008).
  • Independent predictors of Pattern B included gender, race, BMI, and lipid status.
  • Triglyceride was the sole independent predictor of sdLDL (p=0.001).

Conclusions:

  • High prevalence of Pattern B observed, including normolipidaemic cases.
  • Chinese males with dyslipidemia and increased BMI independently predicted Pattern B.
  • Triglyceride levels partially explain ethnic differences in Pattern B prevalence but not fully.
  • Atherogenic normolipidaemia poses significant CVD risk, often overlooked in primary prevention.