Predictive factors of progression in renal function after unilateral nephrectomy in renal malignancy

This study aimed to investigate the predictors of renal function changes after unilateral nephrectomy in renal malignancy.

The clinical data from patients who were pathologically diagnosed with primary renal cancer with preoperative eGFR≥60 mL/min/1.73 m2 and had accepted the unilateral nephrectomy for renal malignant tumors were retrospectively analysed. General information and biochemical indicators of patients were collected before surgery. This study used multiple uni-factor and multi-factor correlation analyses to determine the correlation between postoperative eGFR and preoperative indicators.

After a postoperative follow-up of 119 patients from 3 to 60 months, we found that among 31 factors, urine osmotic pressure and preoperative eGFR were significantly associated with postoperative renal function deterioration. Further analysis indicated that urinary osmotic pressure was an independent risk factor of renal function deterioration. There was a negative correlation between preoperative eGFR and postoperative renal function deterioration. Lymphocyte counts and preoperative eGFR had a significant impact on postoperative renal function deterioration. Urinary osmotic pressure and preoperative eGFR could be used to evaluate the postoperative renal function deterioration.

The postoperative renal function deterioration of patients with renal cell carcinoma was closely related to urine osmotic pressure and preoperative eGFR. The indicators of lymphocyte counts and preoperative eGFR had a significant impact on the progression of patient renal dysfunction. Urine osmotic pressure and preoperative eGFR can be utilized as an evaluation index for postoperative renal function deterioration.