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Related Experiment Videos

D-xylose testing: a review.

R M Craig1, A J Atkinson

  • 1Gastroenterology Section, Northwestern University Medical School, Chicago, Illinois.

Gastroenterology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

D-xylose testing effectively diagnoses small intestinal malabsorption in adults and children. Different D-xylose test protocols offer high accuracy for various patient groups and malabsorption causes.

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Area of Science:

  • Gastroenterology
  • Clinical Diagnostics
  • Biochemistry

Background:

  • D-xylose testing is a key diagnostic tool for small intestinal malabsorption.
  • Recent kinetic studies provide new insights into D-xylose test efficacy.
  • Understanding optimal D-xylose test protocols is crucial for accurate diagnosis.

Purpose of the Study:

  • To review the clinical efficacy of D-xylose testing based on recent kinetic data.
  • To evaluate the diagnostic performance of various D-xylose test protocols.
  • To determine the utility of D-xylose testing in different patient populations.

Main Methods:

  • Review of kinetic studies on D-xylose absorption and excretion.
  • Analysis of data from standard 25-g D-xylose urine and serum tests in adults.

Related Experiment Videos

  • Evaluation of 1-h serum D-xylose levels in adults, pediatrics, and specific patient groups.
  • Assessment of the [14C]D-xylose breath test for bacterial overgrowth.

    • Main Results:

    • The standard 25-g D-xylose test shows >95% specificity and sensitivity for proximal small intestinal malabsorption.
    • 1-h serum D-xylose levels are valuable for malabsorption assessment in renal insufficiency and the elderly.
    • The 5-g D-xylose 1-h serum test in pediatrics demonstrates >91% sensitivity and near 100% specificity.
    • The [14C]D-xylose breath test effectively identifies malabsorption due to small intestinal bacterial overgrowth.

    Conclusions:

    • D-xylose testing remains a highly effective method for diagnosing small intestinal malabsorption.
    • Specific D-xylose test protocols are optimized for different age groups and clinical scenarios.
    • D-xylose testing aids in differentiating malabsorption causes, including bacterial overgrowth.