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Updated: Dec 10, 2025

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
Published on: November 3, 2023
Diaphragm Muscle Adaptations in Health and Disease
Matthew J Fogarty1, Gary C Sieck1
1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Abstract:
Breathing is achieved without thought despite being controlled by a complex neural network. The diaphragm is the predominant muscle responsible for force/pressure generation during breathing, but it is also involved in other non-ventilatory expulsive behaviors. This review considers alterations in diaphragm muscle fiber types and the neural control of the diaphragm across our lifespan and in various disease conditions.
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