Uveitis-induced Refractory Ocular Hypotony Managed with High-dose Latanoprost

Area of Science:

• Ophthalmology
• Rheumatology
• Pharmacology

Background:

• Behcet's disease is a multisystem inflammatory disorder.
• Ocular hypotony is a severe complication of Behcet's disease, often leading to vision loss.
• Refractory ocular hypotony poses significant management challenges.

Observation:

• A 26-year-old male with Behcet's disease presented with vision loss and severe ocular hypotony.
• Previous treatments including corticosteroids, ibopamine, vitrectomy, and silicone oil injection were ineffective.
• High-dose topical latanoprost was initiated for management.

Findings:

• Topical latanoprost led to a sustained increase in intraocular pressure (IOP) by 5 mm Hg.
• The IOP stabilized at 7 mm Hg and remained stable for 24 months.
• This indicates a positive response to high-dose latanoprost in a refractory case.

Implications:

• High-dose topical latanoprost may be a viable therapeutic option for uveitis-induced refractory ocular hypotony.
• This case highlights a potential treatment advancement for severe ocular complications of Behcet's disease.
• Further research is warranted to explore the efficacy and safety of this approach.