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Predictive Low Glucose Suspend Algorithm in Real Life: A Five-Year Follow-Up Retrospective Analysis
Claudio Tubili1, Daniela Pollakova1, Maria Rosaria Nardone1
1Diabetes Unit, "S. Camillo-Forlanini" Hospital, Rome, Italy.
Journal of Diabetes Science and Technology
|September 1, 2020
Summary
Sensor-augmented pumps with predictive low glucose suspend function (PLGS-SAP) significantly improved glycemic control in type 1 diabetes patients. This technology also helped maintain stable body weight over five years.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Medical Devices
Background:
- Type 1 diabetes (T1D) management requires continuous monitoring and intervention to prevent complications.
- Sensor-augmented insulin pumps with predictive low glucose suspend function (PLGS-SAP) aim to mitigate hypoglycemia and enhance patient quality of life.
Purpose of the Study:
- To investigate the long-term effects of PLGS-SAP on metabolic outcomes and diabetic complications in adults with T1D.
- To assess the impact of PLGS-SAP on cardiovascular events and overall clinical status.
Main Methods:
- A retrospective study followed 139 adults with T1D using continuous subcutaneous insulin infusion (CSII) for over 10 years.
- Participants were divided into two groups: 71 using PLGS-SAP and 68 on conventional insulin pumps over a 5-year period.
- Evaluated outcomes included HbA1c, acute/chronic diabetic complications, BMI, and device utilization.
Main Results:
- Group 1 (PLGS-SAP) showed a significant reduction in HbA1c (7.5% to 7.0%, P=.02), while Group 2 did not (7.5% to 7.4%, P=.853).
- Body mass index (BMI) increased significantly in Group 2 (P<.001) but remained stable in Group 1 (P=.887).
- No significant differences were observed in acute/chronic complications or device utilization between groups.
Conclusions:
- PLGS-SAP is effective in improving glycemic control (HbA1c) for T1D patients using CSII.
- PLGS-SAP aids in maintaining stable body weight, contributing to better metabolic management.
- The technology demonstrates efficiency in long-term T1D management without increasing other complications.
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