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Updated: Dec 10, 2025

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
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Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins

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Computing Potential of the Mean Force Profiles for Ion Permeation Through Channelrhodopsin Chimera, C1C2

Chad Priest1, Monika R VanGordon2, Caroline Rempe1

  • 1Sandia National Laboratories, Albuquerque, NM, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 1, 2020
PubMed

Keywords:
Free energiesMolecular dynamicsNanotechnologyOptogeneticsPotential of mean force (PMF)Reaction coordinate (RC)Statistical mechanicsUmbrella sampling (US)Weighted histogram method (WHAM)

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