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Local Macular Thickness Relationships between 2 OCT Devices
Golnoush Mahmoudinezhad1, Vahid Mohammadzadeh1, Navid Amini2
1Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Ophthalmology. Glaucoma
|September 1, 2020
Summary
Optical Coherence Tomography (OCT) devices show high correlation in ganglion cell-inner plexiform layer (GCIPL) thickness measurements, but are not interchangeable. Differences in GCIPL measurements depend on superpixel location and thickness.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Accurate measurement of retinal nerve fiber layer thickness is crucial for glaucoma diagnosis and monitoring.
- Optical Coherence Tomography (OCT) is a key technology for in vivo imaging of the macula and optic nerve head.
Purpose of the Study:
- To compare local ganglion cell-inner plexiform layer (GCIPL) thickness measurements between Cirrus and Spectralis OCT devices.
- To identify factors influencing discrepancies in GCIPL thickness measurements between the two OCT devices.
Main Methods:
- A cross-sectional study involving 69 glaucoma eyes from 63 patients with significant visual field defects.
- Macular volume scans from Cirrus and Spectralis OCT devices were analyzed using aligned superpixels.
- Spearman's correlations and Bland-Altman plots were used to assess agreement, and linear mixed models explored influencing factors.
Main Results:
- High pooled Spearman's correlation (0.97) was observed between Cirrus and Spectralis GCIPL thickness measurements.
- Bland-Altman analysis revealed systematic bias, with Spectralis measurements increasing relative to Cirrus with greater superpixel thickness.
- Superpixel location and thickness significantly influenced measurement differences (P < 0.001).
Conclusions:
- Local GCIPL thickness measurements from Cirrus and Spectralis OCT devices are highly correlated but not interchangeable.
- Measurement discrepancies are influenced by the specific location and thickness of the analyzed retinal areas (superpixels).
- Clinicians should be aware of potential differences when comparing GCIPL measurements between these OCT devices.
