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Organoids in Translational Oncology
Marco Tatullo1, Benedetta Marrelli2, Caterina Benincasa2
1Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70124 Bari, Italy.
Journal of Clinical Medicine
|September 2, 2020
Summary
Tumoroids, or tumor-like organoids derived from patient tumors, are revolutionizing translational oncology. These 3D models enhance understanding of cancer biology and accelerate the development of targeted therapies.
Area of Science:
- Oncology
- Translational Medicine
- Biofabrication
Background:
- Current cancer research relies on 2D cell cultures, limiting its translation to clinical practice.
- 3D printing enables biofabrication of matrices mimicking tumor microenvironments.
- Organoids, specifically 'tumoroids,' are emerging as advanced models for cancer research.
Purpose of the Study:
- To review the application of organoids in translational medicine for oncology.
- To highlight the use of tumoroids in understanding cancer mechanisms.
- To discuss strategies for effective targeted therapies using tumoroids.
Main Methods:
- Review of scientific literature on organoids and tumoroids.
- Focus on 3D biofabrication techniques.
- Analysis of applications in cancer biology and targeted therapy development.
Main Results:
- Tumoroids accurately mimic patient-specific tumor extracellular environments.
- Organoid models facilitate investigation of cancer onset and growth mechanisms.
- Tumoroids show promise for predicting and improving targeted therapy efficacy.
Conclusions:
- Tumoroids represent a significant advancement in translational oncology.
- These 3D models are crucial for personalized medicine and drug development.
- Further research on tumoroids will accelerate the translation of preclinical findings into clinical treatments.
