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Strong Positive Correlation between TSH and Ghrelin in Euthyroid Non-Growth Hormone-Deficient Children with Short

Katarzyna Adamczewska1, Zbigniew Adamczewski1,2, Anna Łupińska1

  • 1Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.

Molecules (Basel, Switzerland)
|September 2, 2020
PubMed

Insights

In children with idiopathic short stature, higher ghrelin levels correlate with thyroid stimulating hormone (TSH). Higher TSH is linked to reduced nocturnal growth hormone (GH) and insulin-like growth factor I (IGF-I).

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Axis
  • Thyroid Function

Background:

  • Childhood growth relies on hormones and growth factors.
  • Previous studies linked ghrelin and TSH in thyroid dysfunction.
  • Ghrelin suppressed GH and IGF-I in hypothyroid rats.

Purpose of the Study:

  • To investigate ghrelin, TSH, GH, and IGF-I relationships in euthyroid children with idiopathic short stature (ISS).
  • To analyze correlations between these hormones in prepubertal children with ISS.

Main Methods:

  • Analyzed ghrelin, GH (stimulating tests, nocturnal), IGF-I, TSH, FT4, and FT3.
  • Included 85 euthyroid prepubertal children with ISS (36 girls, 49 boys).
  • Statistical correlation analysis was performed.

Main Results:

  • Confirmed a strong positive correlation between ghrelin and TSH (r = +0.44, p < 0.05).
  • Children with higher normal TSH showed higher ghrelin but lower nocturnal GH and IGF-I.
  • TSH variations did not impact free thyroxine (FT4) or free triiodothyronine (FT3) levels.

Conclusions:

  • Ghrelin and TSH secretion are closely related in prepubertal euthyroid children with ISS.
  • Elevated TSH is associated with decreased nocturnal GH and IGF-I levels.
  • Further research is needed to understand the impact on growth processes.

Keywords:
childrenfree thyroxinefree triiodothyronineghrelingrowth hormoneidiopathic short statureinsulin-like growth factor Ithyroid stimulating hormone

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