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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Prodrugs01:30

Prodrugs

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Structure-Activity Relationships and Drug Design01:28

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Prescription, Nonprescription and Orphan Drugs01:02

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Drug Biotransformation: Overview01:16

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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Drug Biotransformation: Overview01:28

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Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
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Related Experiment Video

Updated: Dec 10, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Perspectives on Drug Repurposing.

Alejandro Schcolnik-Cabrera1, Daniel Juárez-López2, Alfonso Duenas-Gonzalez3

  • 1Departement de Biochimie et Medecine Moleculaire, Universite de Montreal, C.P. 6128, Succursale Centre- Ville, Montreal, QC, Canada.

Current Medicinal Chemistry
|September 2, 2020
PubMed
Summary

Drug repurposing offers a faster, cheaper, and safer path to new treatments for complex diseases. Increased investment and awareness can make effective repurposed drugs more accessible to patients.

Keywords:
Drug repurposingGene-chemical Structure-target Networkscommon diseasesdrug discovery and developmentpharmaceutical companiesrepurposed compounds

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Area of Science:

  • Pharmacology and Drug Development
  • Public Health
  • Health Economics

Background:

  • Complex common diseases pose a significant societal burden, necessitating improved treatments.
  • Current drug discovery is costly, leading to high medication prices and limited patient access.
  • Traditional drug development faces challenges in speed, cost, and safety.

Purpose of the Study:

  • To highlight drug repurposing as a strategy to accelerate access to effective and affordable treatments.
  • To advocate for increased investment and awareness to support drug repurposing initiatives.
  • To reduce prescribing bias and promote the use of repurposed drugs for common conditions.

Main Methods:

  • Reviewing the advantages of drug repurposing over traditional drug discovery.
  • Analyzing the economic and safety benefits of repurposing existing compounds.
  • Discussing the need for multi-sectoral investment and community engagement.

Main Results:

  • Drug repurposing expedites preclinical and clinical development phases.
  • Repurposing reduces research and development costs and mitigates biosafety risks.
  • Enhanced awareness can overcome prescribing bias, favoring accessible repurposed medications.

Conclusions:

  • Drug repurposing presents a viable solution for developing safer, more effective, and affordable treatments.
  • Collaborative funding from government, society, and private investors is crucial for clinical development.
  • Promoting drug repurposing can improve patient access to essential medications for common diseases.