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Updated: Dec 10, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Clinical implications of C6 complement component deficiency.

Christine K Rauscher1, Merritt L Fajt1, Jodie Bryk2

  • 1From the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and.

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Terminal complement component deficiencies increase the risk of neisserial infections. C6 deficiency, the most common form, can manifest later in life with Meningitis infections.

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Area of Science:

  • Immunology
  • Infectious Diseases

Background:

  • Terminal complement component deficiencies are established risk factors for severe neisserial infections.
  • Understanding these deficiencies is crucial for managing recurrent infections.

Observation:

  • A case of C6 deficiency in a 56-year-old patient with meningitis and chronic rash is presented.
  • This case highlights the varied clinical presentations of terminal complement deficiencies.

Findings:

  • C6 deficiency is the most prevalent terminal complement component deficiency.
  • Late-onset Neisseria meningitidis infections can occur in individuals with C6 deficiency.

Implications:

  • Screening for terminal complement component deficiency using CH50 assays is recommended.
  • This review provides clinical pearls for allergists/immunologists managing these patients.