Autoimmune Reaction and the Management of Recurrent Bioprosthetic Pulmonary Valve Dysfunction

Francis E Ezekwueme1, Bryan H Goldstein2, Carley Bright2

  • 1Heart Institute, UPMC Children's Hospital of Pittsburgh and UPMC Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA.

JACC. Case Reports
|September 26, 2025
PubMed
Summary

A rare case of bioprosthetic pulmonary valve failure was caused by an allergic reaction to molybdenum. Allergy testing identified the metal, and treatment with immunosuppression and antihistamines improved valve function.

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