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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Bioinspired MXene-integrated colloidal crystal arrays for multichannel bioinformation coding.

Feika Bian^1,2,3, Lingyu Sun^1,3, Lijun Cai^1,3

¹Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China.

Proceedings of the National Academy of Sciences of the United States of America

|September 2, 2020

Summary

This study introduces a novel bioinspired photonic crystal array integrated with MXene for efficient bioinformation coding. This method offers high-throughput data encryption and readout by utilizing fluorescence quenching and enhanced contrast.

Keywords:

MXene bioinspired colloidal crystal structural color wettability

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Last Updated: Dec 10, 2025

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Bridging the Bio-Electronic Interface with Biofabrication

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Published on: June 6, 2012

Area of Science:

Materials Science
Biotechnology
Information Technology

Background:

The information explosion necessitates advanced data storage solutions.
Bioinformation coding offers high capacity and long-term data stability.
Existing methods require improvement in throughput and encryption.

Purpose of the Study:

To develop an innovative bioinspired MXene-integrated photonic crystal (PhC) array for multichannel bioinformation coding.
To leverage the unique properties of MXene and PhC for secure and efficient data storage.
To demonstrate a high-throughput method for information encoding and encryption.

Main Methods:

Fabrication of PhC arrays inspired by beetle structures.
Integration of MXene nanosheets using mussel-inspired dopamine.
Utilizing fluorescence resonance energy transfer (FRET) for signal modulation.
Employing quantum dot (QD) modified DNA probes for target detection.

Main Results:

MXene nanosheets effectively quenched QD fluorescence, enabling target-specific signal readout.
The PhC array provided a stable substrate with enhanced structural color contrast.
The developed system demonstrated high-throughput information encoding and encryption capabilities.
Successful readout of encrypted information via fluorescence signal observation.

Conclusions:

The bioinspired MXene-integrated PhC array is a promising platform for advanced bioinformation coding.
This strategy enables secure, high-capacity, and high-throughput data storage.
The approach opens new avenues for bioinformation encoding and encryption applications.