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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Current mechanisms in obesity and tumor progression
Andin Fosam1,2, Rachel J Perry1,2
1Department of Internal Medicine.
Current Opinion in Clinical Nutrition and Metabolic Care
|September 2, 2020
Summary
Obesity significantly increases cancer risk and worsens prognosis by promoting tumor growth through complex, interacting mechanisms. Understanding these links is crucial for developing new cancer prevention and treatment strategies targeting adipose tissue.
Area of Science:
- Oncology
- Metabolic Syndrome
- Cancer Biology
Background:
- Hyperadiposity, a hallmark of obesity, presents a significant risk factor for cancer development and impacts patient prognosis.
- Existing research has proposed several mechanistic links between obesity and tumor progression, but a comprehensive understanding of these interactions remains incomplete.
- The dynamic interplay of various obesity-related factors within the tumor microenvironment is not fully elucidated in current literature.
Purpose of the Study:
- To review the current understanding of obesity's impact on cancer development and progression.
- To explore the multifaceted mechanisms by which obesity influences tumor growth, including inflammation, hormones, and adipokines.
- To provide insights into targeting adipose tissue for cancer prevention and treatment strategies.
Main Methods:
- Literature review focusing on recent findings regarding obesity and cancer.
- Analysis of proposed mechanistic frameworks linking obesity to tumor progression.
- Synthesis of information on the tumor microenvironment and its interaction with obesity-related factors.
Main Results:
- Obesity influences tumor development and progression through various interconnected pathways.
- Key mechanisms include chronic inflammation, pro-inflammatory cytokines, adipokines, hormones, and genetic factors.
- These factors interact within the tumor microenvironment to promote tumor growth and affect prognosis.
Conclusions:
- Obesity is a critical factor in cancer risk and outcome, mediated by complex biological mechanisms.
- Targeting adipose tissue holds promise for novel cancer prevention and treatment approaches.
- Further research is needed to fully define and exploit the interactions between obesity and cancer biology.
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