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Successful Management of Pan-Resistant Acinetobacter baumannii Meningitis without Intrathecal or Intraventricular

Shirin Sayyahfar1, Farhad Abolhasan Choobdar2, Mahdi Mashayekhi3

  • 1Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.

Infection & Chemotherapy
|September 2, 2020
PubMed

Insights

This study reports a successful treatment of a neonate with pan-resistant Acinetobacter baumannii meningitis using intravenous colistin, meropenem, and rifampin. This combination offers a potential therapeutic option when other methods are not feasible.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Neonatalogy

Background:

  • Acinetobacter baumannii is a significant cause of nosocomial infections, frequently exhibiting multidrug and pan-resistance.
  • Meningitis caused by pan-resistant A. baumannii presents a therapeutic challenge due to limited effective antibiotics and poor blood-brain barrier penetration of polymyxins.

Observation:

  • A neonate developed nosocomial meningitis due to pan-resistant A. baumannii.
  • Intravenous administration of colistin, meropenem, and rifampin was employed for treatment.

Findings:

  • The neonate with pan-resistant A. baumannii meningitis achieved successful treatment outcomes.
  • Intravenous colistin, in combination with meropenem and rifampin, demonstrated efficacy.

Implications:

  • Intravenous colistin, combined with meropenem and rifampin, may be a viable treatment option for pan-resistant A. baumannii meningitis.
  • This therapeutic approach could be considered when intrathecal injection or intraventricular devices are not feasible, particularly in neonates.
Keywords:
Acinetobacter baumanniiColistinMeningitisMulti-drug resistantNeonate, Polymyxin

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