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Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell
Liqi Wan1, Sik Lok Lam1, Hung Kay Lee1
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. lams@cuhk.edu.hk.
Chemical Communications (Cambridge, England)
|September 2, 2020
Abstract:
Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.
