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Obstructive sleep apnea and respiratory center regulation abnormality
Liang Si1, Jing Zhang1, Yan Wang1
1Respiratory Department, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Sleep & Breathing = Schlaf & Atmung
|September 2, 2020
Summary
Understanding respiratory control in obstructive sleep apnea (OSA) is key for personalized treatment. This review explores how breathing regulation changes during sleep and wakefulness in OSA patients.
Area of Science:
- Sleep Medicine
- Respiratory Physiology
- Neurology
Background:
- Obstructive sleep apnea (OSA) is a complex condition.
- Personalized treatment relies on understanding disease mechanisms.
- Pathophysiology of OSA is not fully understood.
Purpose of the Study:
- To review variations in respiratory center regulation during sleep and wakefulness in OSA patients.
- To examine current literature on respiratory control in OSA.
- To identify detection methods and phenotypic treatments for respiratory control.
Main Methods:
- Literature search of PubMed database up to December 31, 2019.
- Review of studies on respiratory center regulation in OSA.
- Analysis of chemoresponsiveness to hypoxia and hypercapnia during sleep stages.
Main Results:
- Ventilatory control instability in OSA is linked to sleep stage-dependent chemoresponsiveness.
- Chemosensitivity varies at different times, contributing to OSA.
- Identifying pathophysiological mechanisms can stabilize the breathing center.
Conclusions:
- Further research into OSA mechanisms is crucial.
- Mechanism-based research will inform symptom research.
- Novel treatment opportunities for OSA patients can be developed.
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