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Related Experiment Video

Updated: Dec 10, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Evaluation of Renal Function in Obstructed Ureter Model Using ^99mTc-DMSA.

Seok Jin Jang¹, Byung Soo Choi², Seok Hwa Choi³

¹Onnuri Animal Medical Center, Cheongju, Republic of Korea.

In Vivo (Athens, Greece)

|September 3, 2020

Summary

Technetium Tc-99m labeled dimercaptosuccinic acid (99mTc-DMSA) scintigraphy effectively detects changes in renal perfusion and size in rabbits with unilateral ureter obstruction, aiding obstructive renal disease studies.

Keywords:

99mTc-DMSA Renal function rabbit ureter obstruction

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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

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Published on: July 18, 2025

Area of Science:

Nuclear medicine
Renal pathophysiology
Diagnostic imaging

Background:

Urinary obstruction impairs urinary drainage, potentially causing renal deterioration.
Investigating non-invasive methods to assess obstructive renal diseases is crucial.
99mTc-DMSA renal scintigraphy offers a potential tool for evaluating renal function during obstruction.

Purpose of the Study:

To evaluate the utility of 99mTc-DMSA renal scintigraphy in a rabbit model of unilateral ureter obstruction.
To assess changes in renal function and morphology following ureter obstruction.

Main Methods:

Unilateral ureter obstruction was induced in rabbits by complete ligation of the right ureter.
Renal function and perfusion were assessed using 99mTc-DMSA scintigraphy over 4 weeks.
Histological and hematological examinations complemented the scintigraphic findings.

Main Results:

Significant and rapid reduction in renal perfusion was observed in obstructed kidneys.
Obstructed kidneys showed progressive enlargement compared to normal contralateral kidneys.
Histopathology revealed tubular atrophy, interstitial expansion, and inflammation in obstructed kidneys.

Conclusions:

99mTc-DMSA scintigraphy is a sensitive, non-invasive method for assessing renal function in unilateral kidney disease.
The technique can detect functional and morphological changes associated with obstructive nephropathy.
This model provides valuable insights into the progression and assessment of obstructive renal diseases.