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Updated: Oct 8, 2025

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Assessment of Individual Renal Function Using 99mTc-MAG3 Renography
Hyeong-Joon Lim1, Seok Hwa Choi2
1College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Background/Aim:
This study performed 99mTc-MAG3 renal scintigraphy on rabbit kidneys and evaluated its ability to identify obstructive or non-obstructive kidneys.
Materials And Methods:
Renal function was assessed during a four-week post-obstruction period by obtaining planar images of 99mTc-MAG3 activity following an ear vein injection. The individual renal function was evaluated by renal scintigraphy in conjunction with histopathological and morphological examinations.
Results:
The renal perfusion of 99mTc-MAG3 in the right kidney with a ureteral obstruction decreased with time. The width, height, and cortical thickness of the obstructed right kidney were significantly larger than those of the left kidney. A histopathological examination four weeks after the ureteral obstruction revealed a typical pattern of urinary tract obstruction, including multiple tubules, enlargement of the interstitial area, and cytoplasmic vacuoles.
Conclusion:
99mTc-MAG3 renal scintigraphy provides the kidney shape and size and can identify potential obstructive and non-obstructive kidneys in rabbits.
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