Real-time multi-frequency ultrasound imaging for quantitative lung ultrasound - first clinical results

Lung ultrasound imaging is a fast-evolving field of application for ultrasound technologies. However, most diagnoses are currently performed with imaging protocols that assume a quasi-homogeneous speed of sound in the volume of interest. When applied to the lung, due to the presence of air, this assumption is unrealistic. Consequently, diagnoses are often based on imaging artifacts and thus qualitative and subjective. In this paper, we present an image formation protocol that is capable of capturing the frequency dependence of well-known artifacts (B-lines) and visualizing it in real time, ultimately providing a quantitative assessment of the signals received from the lung. Previous in vitro studies have shown the potential of B-lines native-frequency for the characterization of bubbly medium, but this paper presents the first results on clinical data. The image formation process has been designed to work on lung tissue, and ultrasound images generated with four orthogonal bands centered at 3, 4, 5 and 6 MHz can be acquired and displayed in real time. Results show that B-lines can be characterized on the basis of their native frequency in vivo and open the way toward real-time quantitative lung ultrasound imaging.