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Related Experiment Videos

Candida: an increasingly important pathogen in the nursery.

K M Butler1, C J Baker

  • 1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC.

Pediatric Clinics of North America
|June 1, 1988
PubMed
Summary

Neonatal care advances increase survival of premature infants, leading to a rise in invasive candidiasis. This review covers candidal infections, focusing on risk factors, diagnosis, and treatment.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Mycology

Background:

  • Neonatal intensive care advances enable survival of extremely premature infants.
  • Candidiasis, a fungal infection, presents a widening spectrum of disease, with increased invasive cases.
  • This necessitates a comprehensive understanding of candidal infections in vulnerable neonates.

Purpose of the Study:

  • To review the history, microbiology, and epidemiology of candidal infections (superficial and invasive).
  • To detail the pathogenesis and risk factors for invasive candidiasis in neonates.
  • To outline clinical manifestations, diagnosis, and current treatment strategies.

Main Methods:

  • Literature review of historical data, microbiological studies, and epidemiological surveys.

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  • Analysis of pathogenesis and risk factors for invasive candidiasis.
  • Synthesis of information on clinical presentation, diagnostic approaches, and therapeutic interventions.
  • Main Results:

    • Candidiasis has evolved, with increased incidence of invasive forms in neonatal populations.
    • Specific risk factors and pathogenic mechanisms contribute to invasive candidal disease in immature infants.
    • Effective diagnosis and treatment are crucial for improving outcomes.

    Conclusions:

    • Invasive candidiasis is a significant concern in neonatal intensive care units.
    • Understanding risk factors and pathogenesis is key to prevention and management.
    • Multifaceted approaches to diagnosis and treatment are essential for combating neonatal candidiasis.