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Intestinal Failure-Associated Liver Disease in Neonates
Jennifer Fundora1, Susan W Aucott1,2
1Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD.
Neoreviews
|September 3, 2020
Summary
Intestinal failure-associated liver disease (IFALD) is a common complication in neonates receiving parenteral nutrition. Management focuses on transitioning to enteral nutrition and exploring alternative therapies for persistent cases.
Area of Science:
- Neonatology
- Pediatric Gastroenterology
- Hepatology
Background:
- Intestinal failure-associated liver disease (IFALD) is a significant complication in neonates dependent on parenteral nutrition.
- The development of IFALD is multifactorial, influenced by the infant's primary condition and factors like prematurity.
Purpose of the Study:
- To review the epidemiology of IFALD in neonates.
- To identify contributing factors to IFALD development.
- To outline current management strategies for IFALD.
Main Methods:
- Literature review of epidemiological data.
- Analysis of factors contributing to IFALD.
- Synthesis of current clinical management approaches.
Main Results:
- IFALD is prevalent in neonates with intestinal failure requiring parenteral nutrition.
- Multiple infant-specific and disease-related factors contribute to IFALD.
- Management emphasizes safe transition to enteral feeding and alternative treatments.
Conclusions:
- Early identification and management of IFALD are crucial in neonatal care.
- Multifactorial etiology requires a comprehensive approach to prevention and treatment.
- Optimizing nutrition and minimizing parenteral nutrition exposure are key.
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