Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding - ovulation dysfunction...

Area of Science:

• Reproductive Endocrinology
• Clinical Pharmacology
• Women's Health

Background:

• Abnormal uterine bleeding due to ovulation dysfunction (AUB-O) impacts many women.
• Dydrogesterone is a known treatment for irregular cycles, but studies in Chinese populations are limited.
• This study evaluated dydrogesterone's effectiveness in Chinese patients with AUB-O.

Purpose of the Study:

• To assess dydrogesterone's efficacy in regularizing menstrual cycles (MC) in Chinese women with AUB-O.
• To investigate the effects of dydrogesterone on hormonal metabolism, specifically androgens.
• To evaluate the impact on basal body temperature patterns.

Main Methods:

• A prospective, observational, post-marketing study enrolled Chinese women (≥16 years) with AUB-O.
• Patients received dydrogesterone 10 mg daily from day 16 to 25 for at least three cycles.
• Menstrual cycle normalization was defined as cycle length between 21 and 35 days.

Main Results:

• Out of 89 patients completing treatment, 80.9% achieved regular menstrual cycles after three cycles.
• Significant reductions in testosterone and dehydroepiandrosterone sulfate levels were observed (P=0.01 and P=0.031).
• Biphasic basal body temperature was reported by 55.0% of participants.

Conclusions:

• Dydrogesterone is an effective treatment for menstrual cycle regularization in Chinese patients diagnosed with AUB-O.
• The therapy demonstrates a positive impact on hormonal balance by reducing androgen levels.
• Further research can explore long-term effects and broader applications.